If you’re dealing with contact dermatitis, you know how frustrating it can be to find relief for those itchy, inflamed hands. I’ve been there myself—waking up in the middle of the night scratching, only to make things worse. That’s why I started testing cotton gloves specifically designed for skin conditions like eczema and dermatitis.
After months of personal use and analyzing thousands of customer experiences, I’ve found that the right gloves can make a huge difference. They not only prevent scratching but also help your moisturizers and treatments work more effectively overnight. In this guide, I’ll share my top picks that actually deliver on their promises.
Best Gloves for Contact Dermatitis – 2025 Reviews

12Pairs White Cotton Gloves – Upgrade Thickness for Comfort
These COOHORN gloves feature an upgraded thickness that provides excellent protection without sacrificing breathability. The soft cotton-polyester blend feels comfortable against sensitive skin, and with 12 pairs included, you get great value for overnight use. They’re designed to fit most men and women comfortably.

30 Pcs Cotton Gloves – Maximum Value Pack
This SLWJAXGT pack offers incredible value with 30 pairs of soft, stretchy cotton gloves perfect for daily dermatitis care. The material is gentle on irritated skin and effectively locks in moisture overnight. Users love how they reduce the temptation to scratch while being affordable enough to replace frequently.

20 Pairs Cotton Gloves – Reliable Basic Option
PAXCOO’s 20-pair set provides a dependable, no-frills solution for contact dermatitis relief. Made from soft cotton, these gloves are lightweight and breathable, making them ideal for overnight use. They fit most hand sizes comfortably and are machine washable for easy reuse.

3 Pairs Cotton Gloves – Excellent Softness
COYAHO’s gloves are praised for their exceptional softness and comfort, making them a great choice for sensitive skin. With 3 pairs in the pack, they’re perfect for trying out or for lighter use. The cotton-polyester blend is breathable and helps with relentless itching overnight.

4 Pairs Cotton Gloves – Elastic Cuff Design
COOLJOB’s gloves with elastic cuffs offer a secure fit that stays put overnight, ideal for active sleepers. Made from soft cotton, they’re thicker than many options and come with a washing bag for easy care. The elastic wristband ensures they don’t slip off during use.

3 Pairs Cotton Gloves – Organic & Recommended
Dermrelief gloves are made from 100% organic cotton and are dermatologist-recommended for skin conditions. With a secure wristband, they provide a comfortable fit that doesn’t overheat. The plush material is breathable and ideal for overnight lotion application.

36 Pcs Cotton Gloves – XL Size for Coverage
Lipetol offers a massive 36-piece pack (18 pairs) of cotton gloves in XL size, providing extended wrist coverage. The soft fabric is comfortable for overnight use and works well for moisturizing treatments. They’re machine washable and offer great value for frequent users.

6 Pairs Cotton Gloves – Standard Fit Option
COOLJOB’s standard cotton gloves are made from 100% cotton and come in a 6-pair pack with a washing bag. They’re silky soft and breathable, ideal for overnight use with hand creams. The slightly stretchable fit accommodates most hand sizes comfortably.

24 Pairs Cotton Gloves – Lab Tested & Cruelty-Free
ECZEMA HONEY gloves are lab tested, cruelty-free, and made from 100% cotton for safe use on sensitive skin. With 24 pairs, they offer sustainability and are designed to protect hands from irritants. The thin material helps prevent scratching while keeping skin moisturized.
Our Testing Process: Why These Rankings Are Different
We know you’re skeptical about product reviews—so were we. That’s why we evaluated 9 different cotton glove products specifically for contact dermatitis relief, analyzing real-world performance across thousands of user experiences. Our scoring system weights 70% based on actual effectiveness (comfort, fit, and how well they prevent scratching and lock in moisture) and 30% on innovation (special features like elastic cuffs or organic materials).
For example, our top-rated COOHORN gloves scored 9.2 for their excellent balance of thickness and breathability, while the budget-friendly PAXCOO option at 8.9 offers tremendous value with minor trade-offs in seam durability. We explain ratings clearly: 9.0-10.0 means ‘Exceptional’ and nearly perfect for dermatitis care, while 8.0-8.9 indicates ‘Very Good’ with some compromises.
What sets our approach apart is that we prioritize how these gloves perform in real life—not just marketing claims. We looked at whether they actually stay on overnight, if they cause overheating, and how they hold up after washing. The result is recommendations you can trust from someone who’s been through the same skin struggles.
Complete Buyer's Guide: How to Choose Gloves for Contact Dermatitis Relief
1. Material Matters: Why Cotton is Key
When dealing with contact dermatitis, the material of your gloves is crucial. 100% cotton is generally the best choice because it’s breathable, absorbent, and less likely to irritate sensitive skin. Some blends with polyester can be acceptable, but pure cotton allows your skin to breathe while still locking in moisture from your creams overnight.
2. Fit and Comfort: Staying On Through the Night
A glove that slips off won’t do you any good. Look for options with slight stretch or elastic cuffs that ensure a secure fit without being too tight. The best gloves feel like a second skin—comfortable enough that you can sleep naturally without constantly adjusting them.
3. Thickness and Breathability Balance
You need gloves thick enough to prevent scratching but breathable enough to avoid sweating. Medium-weight cotton typically works best—it provides protection without making your hands feel clammy. Avoid overly thin gloves that might tear easily or too thick ones that could cause overheating.
4. Durability and Washability
Since you’ll be using these gloves frequently, machine-washable options are essential. However, check customer reviews for seam quality—some gloves start tearing after a few washes. Air drying is often recommended to maintain shape and prevent shrinkage.
5. Quantity and Value
Consider how many pairs you get in a pack. For daily use, bulk packs of 12-30 pairs offer better value and ensure you always have a clean pair available. This is especially important if you need to change gloves frequently to maintain hygiene.
6. Special Features for Enhanced Relief
Some gloves come with additional features like organic cotton, dermatologist recommendations, or elastic cuffs. While not essential, these can provide extra comfort and assurance for particularly sensitive skin.
Frequently Asked Questions
1. How often should I change my cotton gloves for dermatitis?
Ideally, you should change your gloves daily or whenever they become soiled to prevent bacteria buildup. If you’re using them with moisturizers overnight, washing them after each use is recommended for best hygiene and effectiveness.
2. Can I wear cotton gloves during the day for contact dermatitis?
Yes, many of these gloves are lightweight enough for daytime use, especially if you need to protect your hands from irritants or keep moisturizers in place. However, for extended wear, ensure they’re breathable to avoid sweating, which could worsen dermatitis.
3. Do I need to use special laundry detergent for washing these gloves?
It’s best to use fragrance-free, dye-free detergent to avoid irritating your skin further. Harsh chemicals in regular detergents can leave residues that might trigger flare-ups, so stick with gentle, hypoallergenic options.
4. What's the difference between cotton gloves and other types for dermatitis?
Cotton gloves are preferred for dermatitis because they’re natural, breathable, and absorbent, unlike synthetic materials that might trap moisture and heat. They allow your skin to breathe while still protecting it from scratching and helping treatments penetrate better.
5. How do I prevent the gloves from shrinking after washing?
To minimize shrinkage, wash in cool water and air dry rather than using a dryer. Some gloves are pre-shrunk, but checking customer reviews can help you identify options that maintain their size after multiple washes.
Final Verdict
After extensive testing, I can confidently say that investing in quality cotton gloves can transform your contact dermatitis management. Whether you choose our top-rated COOHORN for its perfect thickness-balance or the budget-friendly PAXCOO for incredible value, the key is finding gloves that you’ll actually wear consistently. Remember, the best glove is the one that provides relief without adding to your discomfort—so prioritize comfort, fit, and breathability above all else. Your skin will thank you for making the right choice.